… First, USP9X is a novel binding partner but not a ubiquitinated substrate of E3 … In support
of our findings, USP9X has been shown to regulate the stability of several E3 ubiquitin ligases, …

… in human breast cancer [127]. On the contrary, another study on breast cancer indicated that
… of breast cancer cells by TGF-β/Smad-mediated epithelial-mesenchymal transition (EMT) […

… To further understand the pathophysiological role of SCF E3 ubiquitin ligase in BRCA, we
… BRCA tissues (n = 60, with 30 breast carcinoma tissues and 30 normal tissue counterparts) (…

… E3 ligases (18, 19). In contrast, acetylation of SNAIL prevents its recognition by E3 ubiquitin
ligases … of EMT and metastasis of triple-negative breast cancer (TNBC) cells driven by the …

… the E3 ubiquitin ligase TRIM56 as the novel modulator of ER alpha signaling in breast cancer…
Here we report that the RING family ubiquitin ligase TRIM56 associates with and stabilizes …

… ubiquitination and protein stability. Here, we report that RNF187, a RING family ubiquitin
ligase, facilitates breast cancer … Our findings revealed not only a novel E3 ligase regulator of …

… Besides, our microarray data also indicated a few novel pathways affected in breast cancer
cells, including NFκB pathway, TGFβ pathway and Wnt pathway [20]. As p53 wild type tends …

… control the ERα signaling activity, is critical for developing novel therapeutics for breast cancer.
… E3 ubiquitin ligase, we further investigate the role of RNF181 on ERα ubiquitination. The …

… containing E3 ubiquitin protein ligase 1 (WWP1) belongs to the HECTD3 E3 ubiquitin ligase
… WWP1 is overexpressed in estrogen receptor α (ERα)-positive breast cancer. Meanwhile, …

… will be discovered and developed as a novel class of anticancer drugs in the foreseeable
future, we are still facing significant challenges so far. Firstly, the specific substrate of …